Detection of chromosome 8 abnormalities in carcinoma of endometrium (endometrial carcinoma of uterus) by fluorescence in situ hybridization( FISH)
- VernacularTitle:荧光原位杂交检测子宫内膜癌8号染色体畸变
- Author:
Yuelan DONG
;
Huaiying FENG
;
Lixin CHEN
- Publication Type:Journal Article
- Keywords:
FISH;
endometrial carcinoma;
chromosome abnormality
- From:China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To study the relationship between chromosome abnormalities and the pathogenesis, development and prognosis of endometrial carcinoma of uterus. Methods: FISH was used to detect endometrial carcinoma, endometrial hyperplasia and normal endometrium , 10 cases in each group, respectively. Results: All of the 10 carcinoma cases had chromosome 8 mutation, including trisomy, monosomy, tetraploid and in 10 cases of endometrial hyperplasia with trisomy of chromosome 8 were found. But there were no mutations of chromosome 8 in the normal group. There was significant difference in the three groups. Conclusions: Abnormalities of chromosome 8 are significantly associated with the process of pathogenesis, development of endometrial carcinoma. The abnormalities may occur in the early stage of the carcinoma, and may have the significant association with clinical stage and pathological differentiation among the patients.
