Clinical analysis of the combined chemotherapy with navelbine concurrent with palliative radiotherapy on stage M, nasopharyngeal carcinoma
- VernacularTitle:长春瑞滨联合化疗加局部姑息放疗治疗M_1期鼻咽癌的临床疗效观察
- Author:
Zhilin LI
;
Jialin YANG
;
Jichuan WANG
- Publication Type:Journal Article
- Keywords:
nasopharyngeal neoplasms;
radiotherapy;
chemotherapy;
metastases;
navelbine
- From:China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To observe the efficacy of combined chemotherapy of navelbine( NVB) and cisplatin ( DDP) plus concurrent palliative local radiotherapy in the treatment of stage M, nasopharngeal carcinoma( NPC). Methods: 21 cases of stage M, NPC received combined chemotherapy of NVB 25 mg/m2 on dl, d8 and DDP 30 mg/m2 on day 1-3. The therapy was repeated every 28 days. All patients were concurrenly treated with palliative radiotherapy for to the distant metastases areas. The radiotherapy dose varied from 15 to 60 Gy. Results: 1.The 1-, 2- and 3- year survival rates of the patients were 71.43%, 14.29% and 9.25% respectively. The median survival time ( MST) was 17 months. 2.The Cox Regression analysis showed that the effect of treatment and the liver invasion are significant prognostic factors. The survival rate is the highest in the patients with lung metastases. Conclusions: This scheme combined chemotherapy of NVB and DDP plus concurrent palliative local radiotherapy can improve the MST of the patients with stage M1 of NPC.
