Clinical observation of oxaliplatin combination with 5-fluorouracil/folinic acid therapy in advanced colorectal cancer
- VernacularTitle:奥沙利铂联合氟尿嘧啶、亚叶酸钙治疗晚期大肠癌的临床观察
- Author:
Jian DING
;
Jiansheng ZHUANG
;
Xinmin LIN
- Publication Type:Journal Article
- Keywords:
advanced colorectal cancer;
oxaliplatin;
5-FU;
CF
- From:
China Oncology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To evaluate the effect and safety of combination chemotherapy with oxaliplatin( L-OHP) plus 5-fluorouracil(5-FU)/folinic acid( CF) in advanced colorectal cancer( ACRC). Methods: 31 patients with ACRC entered the study. L-OHP 130 mg/m2 , iv infusion for 4 hours on day 1; CF 200 mg/m2 , iv infusion for 2 hours followed by 5-FU 500mg/ m , iv infusion for 4 hours from day 1 to day 5, repeated every 3 weeks. Results: There were 10 partial responses, 7 stable disease, 9 progressive disease, the response rate being 38. 5% . The main adverse effect was neuro-sensory toxicity which was seen in 90. 3% of the patients. Vomitting and diarrhea was observed in 58. 1% and 45. 2% of the patients respectively. Bone marrow suppression was mild. Conclusions: L-OHP combination with 5-FU/CF yields an encouraging response with acceptable toxicity in our study. Furthermore clinical reseach is worthwhile.
