Comparative study of gene polymorphism distribution of tumor necrosis factor-beta in Chinese Han population with systemic lupus erythematosus and different race
- VernacularTitle:肿瘤坏死因子?基因多态性在中国汉族SLE病人中的分布特点及与不同人种的比较研究
- Author:
Shaoqing JU
;
Jianhua ZHU
;
Jihu QIAN
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor-beta Genetic polymorphism Polymerase chain reaction-restriction fragment length polymorphism
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the gene polymorphism distribution of tumor necrosis factor-beta(TNF?) with SLE patient and different race in Chinese Han population of Jiangsu province.Methods:DNA samples were extraced from 168 EDTA-blood of unrelated healthy individuals and 66 SLE patients.TNF? alleles were typed using polymerase chain reaction-restrication fragment length polymorphism(PCR-RFLP). Results:The alleles frequencies of TNF? was higher significantly in Chinese Han population than in the White race;the gene frequencies of the TNF?*2 was higher significantly in SLE patients than in the normal controls(SLE patients 67.4%,normal controls 55.1%,P
