GABA_B receptor subunit GBR1b pan mRNA in absence seizure model
- VernacularTitle:?-氨基丁酸B受体亚单位R1b信使RNA在失神样癫痫发作时的改变
- Author:
Qinchi LU
;
Min SU
;
Yan CAI
- Publication Type:Journal Article
- Keywords:
Epilepsy,absence;
Receptors,GABA B;
RNA,messenger
- From:
Chinese Journal of Neurology
1999;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible mechanism of GABA B receptor subunit and epileptogenesis in absence seizure animal model Methods AY 9944 absence seizure model is developed by abdomenal injection of a cholesterol biosynthesis inhibitor Ay 9944 to neonatal Lon Evan hooded rats In situ hybridization is applied to detect GABA B receptor subunit GBR1b pan mRNA in rat brain of absence seizure Result There is increased hybridization signal in cortex, hippocampus and thalamus, especially in cortex (361?48 nCi/g) and hippocampus CA1 region (327?83 nCi/g)( P value 0 020 and 0 027 respectively) Conclusion The result of this study support the hypothesis that GABA B receptor subunit may be involved and induce seizures in absence epilepsy The finding of subunit change may direct the screen of new antiepileptic drug This finding deserves further study
