An evaluation of isoptin for kidney transplant recipients
- VernacularTitle:维拉帕米拮抗肾移植术后免疫抑制剂毒性作用的研究
- Author:
Jianlin YANG
;
Huasheng LI
;
Yuguo WANG
- Publication Type:Journal Article
- Keywords:
Transplantation;
Kidney;
Isoptin;
Immunosupressive agents;
Drug antagonism
- From:
Chinese Journal of Urology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the use of isoptin in kidney transplants recipients. Methods The graft acute rejection rate,the cyclosporin A daily dose and its trough level and toxicity,the blood pressure and cardiovascular complications,the serum creatinine and blood sugar were studied in cadaveric kidney transplant recipients both with and without the additional use of isoptin. Results With the additional use of isoptin in 44 cadaveric kidney transplant recipients,the acute rejection rate has not increased.After using isoptin for 2 weeks,CsA blood level has been increased 25.5% whereas the CsA dose been cut down 32.6 %.So,drug expense dropped about 30.0% and CsA toxicity (hand tremble,insomnia) was slightly decreased. Conclusions Isoptin does not inecease the graft acute rejection rate yet makes the CsA dose and its toxicity less.
