Effects of silicone gel sheeting on hypertrophic scar
- VernacularTitle:硅凝胶膜对增生性瘢痕的影响
- Author:
Dongli FAN
;
Hueiyuang LI
;
Guangxia XIAO
- Publication Type:Journal Article
- Keywords:
Cicatrix, hypertrophic;
Membranae;
Suppressor factors, immunologic
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects and mechanism of silicone gel sheeting on hypertrophic scar. Methods Using human hypertrophic scar as a research object, the changes of fibroblast, collagen metabolism and cytokine expression were observed to study the effects of silicone gel sheeting on hypertrophic scar by clinical observation, histomorphology and immunohistochemistry. Results Compared with the control group, the hypertrophic scar became thin, soft and light markedly, and the expression of TGF ? 1, TGF ? (RI) and ? SM actin were significantly decreased in therapeutic group. Conclusion Silicone gel sheeting may have an influence on scar via inhibiting the expression of TGF ? 1, TGF ?(RI) and ? SM actin in fibroblasts.
