Clinical Diagnostic Value of CT Scan and Serum Tumor Markers Determination for SCLC
- VernacularTitle:小细胞肺癌的CT扫描和分子标志物检测的临床应用研究
- Author:
Chunfeng HU
;
Xu WANG
;
Kai XU
;
Xiuling WANG
- Publication Type:Journal Article
- Keywords:
small-cell lung cancer(SCLC);
tomography, X-ray computed;
neuron-specific enolase(NSE);
Cyfra21-1;
enzyme-linked immunoabsorbent assay (ELISA)
- From:
Journal of Practical Radiology
1992;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinic diagnosis value of CT scan and the determination of serum NSE, Cyfra21-1 for SCLC. Methods ① The CT findings and pathologic basis of 220 cases with SCLC were analyzed retrospectively.② Between February 2000 and December 2001, 120 consecutive patients with pulmonary lesions by CT scan, which suspiciously suffered lung cancer, were studied prospectively. Serum samples were obtained by venous puncture from all patients 1 week prior to surgery or puncture biopsy. The serum concentration of NSE, Cyfra21-1 were determinated using ELISA. According to the pathologic result, the diagnostic value of CT scan, NSE and Cyfra21-1 were evaluated.Results ① Most CT findings of SCLC were central and spindly or eggplant-shape mass, hilar and/or mediastinal lymph nodes enlargement.The obstructive pulmonary lesions were found rarely.② Using CT scan, NSE and Cyfra21-1 alone, the sensitivity were 75%,72.5% and 32.5%,the specificity were 73.75%, 83.75% and 48.75%,the accuracy were 74.16%, 81.67% and 43.33% respectively. With combination of CT scan and NSE, the diagnostic accuracy was 78.3%, and the sensitivity was 87.5%. However, CT scan combined with Cyfra21-1 can not be improve the diagnostic value. Conclusion SCLC has specific CT findings. The sensitivity of CT scan was 75%, combinated with NSE, its accuracy was higher(78.3%), and the sensitivity was 87.5%.
