Influence of p-glycoproteine and metabolism of chlorpheniramine in mice
- Author:
Bui Tung Hiep
- Publication Type:Journal Article
- Keywords:
p-glycoproteine, chlorpheninamine
- MeSH:
Chlorpheniramine;
Glycoproteins;
Metabolism;
Mice;
Animal Experimentation
- From:Pharmaceutical Journal
2004;44(1):19-21
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Chlorpheniramine (CPAM) is a chiral antihistaminic drug commercialized as a racemic mixture. The intestinal investigated in rat using in vitro experiment. Experiments showed that the absorption is not stereoselective. Moreover, the in vitro metabolism of CPAM are not modified by modulator of P-glycoprotein and cytochromes P450
