Effect of Pentoxifylline on type 1 diabetes in NOD mice
- VernacularTitle:己酮可可碱对NOD小鼠1型糖尿病的影响
- Author:
Junhua HE
;
Lizhen LAN
;
Zhili ZHANG
;
Zhaoying LI
- Publication Type:Journal Article
- Keywords:
Pentoxifylline;
Mice, inbred NOD;
Diabetes mellitus, insulin dependent;
Interferon type Ⅱ (Interferon ?);
Tumor necrosis factors;
Interleukin 10
- From:
Chinese Journal of Endocrinology and Metabolism
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of phosphodiesterase inhibitor pentoxifylline (PTX) on type 1 diabetes in NOD mice and its possible mechanism.Methods Blood glucose, urinary glucose, insulitis and incidence of diabetes were investigated in NOD mice treated with PTX, insulitis was observed by HE staining and the expressions of IFN ?, TNF ?, IL 10 in pancreas were measured by RT PCR technique. Results The incidence of diabetes in the PTX group was 30.0% which was significantly lower than 67.9% in the control group (P
