Effects of angiotensin Ⅱ on the action of ?-adrenoceptor stimulated by isoprenalin in Sprague-Dawley rats
- VernacularTitle:血管紧张素Ⅱ对不同年龄大鼠异丙基肾上腺素激动?受体效应的影响
- Author:
Yanfang LI
;
Jinliang LI
;
Yixin HU
;
Dongyun LI
;
Ling WANG
;
Shanchu MU
- Publication Type:Journal Article
- Keywords:
AngiotensinⅡ;
Isoproterenol;
cyclic AMP;
Guanine nucleotides
- From:
Chinese Journal of Geriatrics
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of angiotensin Ⅱ(AngⅡ) on cardiac cAMP accumulative levels induced by isoprenalin(Iso) and AngⅡ on positive inotropic response induced by Iso stimulation ?-adrenoceptor (?-AR) in 3.5- and 12.0- months-old rats. Methods Radioimmunoassay and functional experiment of isolated left atrias were applied to measure the levels of cAMP and cGMP and the positive inotropic response in the hearts. Results Iso increased cAMP accumulation in 3.5-month-old rats〔(1 027?169)pmol/mg vs (1 400?267)pmol/mg,P
