Hypercholesterolemia accelerates the amyloid pathology in model mice induced by aluminum intoxication
- VernacularTitle:高胆固醇血症促进淀粉样蛋白在铝中毒小鼠脑内沉积
- Author:
Henghua LI
- Publication Type:Journal Article
- Keywords:
Hypercholesterolemia;
Amyloid;
Aluminum
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the aggravating effects of hypercholesterolemia on the damage to neurons induced by aluminum intoxication in mice.Methods:Aluminum was given by gavage with Al 400 mg/(kg.d) for 10 weeks.Mice were placed on high-cholesterol diet the third week after Al was given.Results:The spatial recognition ability decreased significantly(P
