Clinical significance of transforming growth factor ?_1 in human bladder transitional cell carcinomas
- VernacularTitle:膀胱癌转化生长因子?_1过表达的临床意义
- Author:
Xin YAO
;
Yanxue LIU
;
Hua CHEN
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Carcinoma,transitional cell;
Transforming growth factor ? 1
- From:
Chinese Journal of Urology
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of the aberrant protein expression and mRNA transcription of transforming growth factor ? 1(TGF? 1) on the biological behavior of human bladder transitional cell carcinomas. Methods The expression of TGF? 1 was investigated in 74 specimens of TCCs by SP immunohistochemistry staining, and the level of TGF? 1 mRNA were determined in 43 cases of TCCs by the method of quantitative RT PCR. Results The positives expression rate of TGF? 1 was 89.2%. Superficial tumors had lower overexpressive rate of TGF? 1(33.3%) than the invasive TCCs(83.8%), P
