Association between the apolipoprotein E gene polymorphism and the genetic sensitivity of sporadic Alzheimer's diseases.
- VernacularTitle:载脂蛋白E基因多态性与散发性阿尔茨海默病的关系
- Author:
Jianping JIA
;
Jin ZHANG
;
Min XU
;
Weidong ZHOU
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Apolipoproteins E
- From:
Chinese Journal of Geriatrics
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between apoE alleles and the occurrence of sporadic Alzheimer's disease (SAD) and to compare the alleles relating to the SAD and the vascular dementia (VD). Methods The polymorphism of apoE gene was detected using polymerase chain reaction restriction fragment length polymorphism(PCR RFLP) technique for 58 patients with SAD, 59 patients with VD and 60 normal controls. Results The frequencies of the ?4 and 3/4 genotype in SAD group(19 82% and 25 86%)were significantly higher than those in the controls(5 00% and 6 67%, ? 2=13 87, P 0 05). Conclusions The apoE ?4 allele is a genetic risk factor for the occurrence of SAD.
