Study on the mechanism of Losartan and Amlodipine in ameliorating the glomerular selerosis
- VernacularTitle:洛沙坦、氨氯地平减轻老年前期自发性高血压大鼠肾小球硬化机制的探讨
- Author:
Zhaomei KANG
;
Shanchu MU
;
Xiaoying ZHANG
- Publication Type:Journal Article
- Keywords:
Rats, inbred SHR;
Glomerulosclerosis, focal;
Losartan;
Amlodipine
- From:
Chinese Journal of Geriatrics
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the protective effects of angiotensin Ⅱ recepter antagonist(ATRA)of Losartan and the calcium channel blockade(CCB)of Amlodipine on the SHR rat kidney. Methods The rats were divided into 3 groups,one group received Losartan(30 mg?kg -1 ?d -1 ),another group Amlodipine(10 mg?kg -1 ?d -1 ),for 3 months, while the control group received only water. All rats were tested for blood pressure(BP),proteinuria(UP),angiotensin(ATⅡ),endothelin(ET),kaluretic peptide(KP),atrial natriuretic peptide(ANP),aldosterone(Ald)and the pathological renal lesions,the expression of collagen Ⅳ(CoⅣ)and laminin(LM)were observed in SHR and Wistar kyoto(WKY)rats before and after the treatment. Results Losartan and Amlodipine not only significantly lowered the BP,24 h UP and pathological renal injuries,modulated the relaxation contraction of vascular substances in blood,but also significantly lessened the expression of CoⅣ and LM and ameliorated the glomerular sclerosis in SHR. Conclusions The modulation of Losartan and Amlodipine on the ratio of relaxative and contractive vascular substances in blood and on the extracellular matrix(ECM) metabolism through the ATⅡ, Ald and ET pathways may be one of the mechanism of ATRA and CCB on ameliorating the glomerular sclerosis.
