The expression of ?-catenin and epidermal growth factor receptor in non-small-cell lung cancer and its clinical significance
- VernacularTitle:?连环素和表皮生长因子受体在非小细胞肺癌中表达的临床研究
- Author:
Pinhua PAN
;
Hongzhang YANG
;
Qiong CHEN
- Publication Type:Journal Article
- Keywords:
Lung cancer Growth iactor receptor ?-catenin Immunohistochemistry
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of ?-catenin and epidermal growth factor receptor in non-small-cell lung cancer and its clinical significance. Methods: The expression of ?-catenin and epidermal growth factor receptor in 58 cases of non-small-cell lung cancer tissue sections were detected by immunohistochemistry. Correlations were investigated between fj-catenin and EGFR immunostaining in primary tumors and histological grade, lymph node stage.Results:23 of 58 cases showed strong ?-catenin immunostaining and 27 of 58 cases showed strong EGFR immunostaining. ?-catenin expression showed significant correlation with grades of differentiation. There were significant correlations between ?-catenm and ECFR. expression and lymph node metastasis. Conclusion: The change of ?-catenin and ECFR expression in surgically treated NSCLC are clearly associated with lymph node metastasis and histological grade.
