Repairing Effects of Zinc-metallothionein on Cadmium-Induced Oxidative Damage of Liver and Kidney in Mice
- VernacularTitle:锌金属硫蛋白对镉致肝肾过氧化损伤的修复作用
- Author:
Qiaoyuan YANG
;
Shengzhang DONG
- Publication Type:Journal Article
- Keywords:
Zinc-metallothionein;
Cadmium;
Lipid peroxidation.
- From:
Journal of Environment and Health
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of zinc-metallothionein (ZnMT) on the cadmium-induced oxidative damage of liver and kidney in mice. Methods The model of laboratory animal was established by 14 d-cadmium exposure to Kunming mice. Then the cadmium-poisoning mice were grouped as Cd-ZnMT group and Cd-ZnSO4 group and perfused orally by solution of ZnMT and ZnSO4 for 14 days respectively. The morphological changes of liver and kidney were observed by electron microscope. The contents of malonydiadehyde (MDA), the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in supernatant fluid of liver and kidney were determined. Results The decreases of the contents of MDA, the increases of the activities of SOD and GSH-Px in liver and kidney of mice in Cd-ZnMT and Cd-ZnSO4-exposure group were observed compared with those in cadmium-exposure group, the dose-effect relationships were also found. The increases of the activities of SOD and GSH-Px, the decrease of contents of MDA of liver and kidney, were found in Cd-ZnMT-exposure group compared with those of Cd-ZnSO4-exposure group, but without statistical significances. The morphological damages of liver and kidney observed by electron microscope in mice of cadmium-exposure group were more serious than those in mice treated with solution of ZnMT and ZnSO4 after cadmium exposure. Conclusion ZnMT could repair the lipid peroxidative damages in liver and kidney in mice induced by exposure to cadmium in a certain degree.
