Joint Effects of Over Intake of Fluoride and Iodine-Deficiency on Thyroid Glands of Pregnant Mice and Their Offspring
- VernacularTitle:高氟与低碘对亲代及子代小鼠甲状腺的协同作用
- Author:
Qing CHANG
;
Zicheng LI
- Publication Type:Journal Article
- Keywords:
Fluoride;
Iodine deficiency;
Mice;
Thyroid gland
- From:
Journal of Environment and Health
1992;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effects of high-fluoride intake and iodine-deficiency on thyroid glands of pregnant mice and their offspring. Methods 200 mg/ L sodium fluoride solution was supplied ad.lib. for the adult female Kunming mice before pregnancy and during pregnancy with iodine-sufficiency and iodine-deficiency. The morphological changes and functions of thyroid glands and the body weights of the pregnant mice and their offspring were observed and measured. Results Under the condition of iodine-sufficiency, significantly higher levels of blood T4 in pregnant mice exposed to high-dose fluoride and their offspring were observed compared with those of control group. Significantly heavier body weights were found in 18 d-pregnant mice and 7 d-old offspring compared with those of control group (P
