Protein-bound gamma-carboxyglutamic acid in urine of calcium oxalate calculus formers
- VernacularTitle:草酸钙结石患者尿中蛋白结合型?-羧基谷氨酸的检测意义
- Author:
Shaogang WANG
;
Jihong LIU
;
Yongshang ZHANG
- Publication Type:Journal Article
- Keywords:
Urinary calculi;
Calcium oxalate;
Gamma-carboxyglutamic acid;
High performance liquid chromatography
- From:
Chinese Journal of Urology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of Gla-bound protein and its Gla residue in urinary lithogenesis. Methods Calcium oxalate crystal matrix was produced by calcium oxalate supersaturation crystallization in fresh urine of normal subjects and calcium oxalate stone formers. Protein-bound Gla was determined in the crystal matrix and urine of normal subjects and in the calcium oxalate stone formers by high performance liquid chromatography. Results Protein-bound Gla in the crystal matrix and urine of calcium oxalate stone formers were significantly less than that of normal subjects. Conclusions Highly carboxylated Gla-bound proteins are inhibitory factors of calcium oxalate calculus. Insufficient carboxylation of urinary Gla-bound proteins may be correlated with urinary lithogenesis.
