EFFECTS OF VERAPAMIL ON MYOCARDIAL PROTECTION DURING VALVE REPLACEMENT
- VernacularTitle:异搏定用于瓣膜替换术心肌保护的临床效果
- Author:
Xiusheng FANG
- Publication Type:Journal Article
- Keywords:
Myocardial protection, Vetapamil;
Valve replacement
- From:
Journal of Chongqing Medical University
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Effects of verapamil-potassium cardioplegic solution (CPS) OB myocardial protection were studied durig the ischemic period of aortic cross-ciatnping in patients undergoing valve replacement. 165 patients were divided into two groups.Croupl (n = 84) with cold potassium CPS, in which, Img/L of verapamil was added.Group 2 (n = 81) as control, with cold potassium CPS alone. As compared to the control group the results showed that (1) hearts were rapidly arrested in diastolic phase, electrocardiac activity was depre ssed more completeli; ( 2 ) before cardiac arret or following reperfusion the incidence of ventricular fibrillation were obviously less than control group,recovery of cardiac function after bypass was better ,and incidence of serious low-output syndromewas lower; (3) electron microscopic examination demonstrated myocardial ultrastructural changes, particularly mitochondrial damages were less and milder. It is concluded that verapamil intensifies the myocardial protective effect of cold CPS
