Investigation on interleukin-1 receptor antagonist gene polymorphism in old men with osteoporosis
- VernacularTitle:老年男性骨质疏松症患者白细胞介素1受体拮抗物基因多态性研究
- Author:
Jixing LIANG
;
Lixiang LIN
;
Mingqin CHEN
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Interleukin 1;
Interleukin 1 receptor antagonist;
Polymorphism (Genetics)
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of interleukin 1 receptor antagonist (IL 1Ra) gene polymorphism with osteoporosis in Chinese old men. Methods The allele frequency and the genotype distribution of the second intron of IL 1Ra gene in the groups of senile control (normal bone mineral density, n=65) and senile men with osteoporosis (n=68) were detected by polymerase chain reaction (PCR). Results The frequencyofA 2alleleincontrolgroup was higher than that in osteoporosis group (0.192 vs 0.103, P
