Effect of iodine on HLA-DR expression in cultured thyrocytes from patients with Graves′ disease
- VernacularTitle:碘对Graves病患者甲状腺上皮细胞HLA-DR表达的影响
- Author:
Xiujuan WANG
;
Wenhao QIN
;
Tongsun QIAN
- Publication Type:Journal Article
- Keywords:
Graves′ disease;
Thyroid;
Epithelial cells;
Iodine;
HLA DR antigens
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of iodine on the pathogenesis of Graves′ disease (GD). Methods The thyroid epithelium cells (TEC) from GD patients and para adenoma normal tissue from thyroid adenoma patients wereculturedrespectivelywithdifferentNaⅠconcentrations from 0 to 1 mg/L. The HLA DR expression of TEC was detected with Western blot. Meanwhile, the morphological change of TEC was observed after treatment of NaⅠ by scanning electronmicroscope (SEM). Results (1) When the concentration of NaⅠ in culture medium was over 100 ?g/L, the amount of HLA DR expression of TEC increased in GD group (P
