Effect of gonadotropin-releasing hormone analogue on levels of serum insulin-like growth factor (IGF)-Ⅰ and IGF binding protein-3 in girls with idiopathic central precocious puberty
- VernacularTitle:GnRH类似物对特发性中枢性性早熟女孩血IGF-Ⅰ和IGF结合蛋白-3水平的影响
- Author:
Huamei MA
;
Minlian DU
- Publication Type:Journal Article
- Keywords:
Puberty, precocious;
Gonadotropin releasing hormone;
Insulin like growth factor Ⅰ;
Insulin like growth factor binding protein 3
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To recognize the changes in the somatotropin axis function in girls with idiopathic central precocious puberty (ICPP) treated with GnRH analogue (GnRHa) and to probe into the cause of growth velocity reduction during GnRHa treatment. Methods Fourteen girls with ICPP were studied. Their growth velocities at the beginning and the end of 6th month of GnRHa treatment were observed. Maturation indexes (MI) were got from vaginal smears, and serum E 2, insulin like growth factor (IGF Ⅰ), IGF binding protein 3 (IGFBP 3) concentrations were determined and IGF Ⅰ/IGFBP 3 calculated at the beginning and the end of 6th month of GnRHa treatment. The controls were 13 age matched healthy prepubertal girls. Results After 6 month GnRHa treatment, the growth velocity reduced significantly from (8.23?1.67)cm/y to (6.27?1.54)cm/y (P
