Study on changes of serum nitric oxide and bone metabolism in streptozotocin-induced diabetic rats
- VernacularTitle:糖尿病大鼠一氧化氮与骨代谢变化的研究
- Author:
Yizhen XU
;
Zhizhou SHEN
;
Jingchong FANG
;
Xiufang YANG
;
Xixing ZHU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Nitric oxide;
Osteoporosis;
Rats, sprague Dawley
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum nitric oxide (NO) and bone metabolism in streptozotocin induced early diabetic (STZ DM) rats. Methods Twenty SD rats were divided into 2 groups, 12 STZ DM rats and 8 controls. Fasting blood glucose, HbA 1c , serum insulin, bone mineral density (BMD) (whole body, lumbar and femoral bone), bone metabolic parameters 〔such as serum calcium, vitamin D 3, parathyroid hormone (PTH), calcitonin, osteocalcin, and urinary pyridinoline/creatinine〕, as well as serum NO were measured. Results Compared with the controls, serum NO in STZ DM group significantly elevated 〔(51.3?11.9 vs 38.1?12.0)?mol/L, P
