Serum and cerebrospinal fluid levels of neuron-specific enolase in epileptic patients
- VernacularTitle:癫痫患者血清和脑脊液神经元特异性烯醇化酶的测定
- Author:
Jianyang XU
;
Bo SONG
;
Hongliang LI
- Publication Type:Journal Article
- Keywords:
Epilepsy;
Phosphopyruvate hydratase;
Cerebrospinal fluid
- From:
Chinese Journal of Neurology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore neuronal damage in epileptic patients after seizures.Methods The serum and cerebrospinal fluid (CSF) levels of neuron-specific enolase (NSE) in the epileptic patients were dynamically determined after seizures by enzyme-linked immuno-sandwich assy. Results The serum and CSF levels of NSE in the epileptic patients were markedly increased after seizures. The serum levels of NSE peaked 1 day after seizure, decreased about one week later,and then returned to normal after two weeks or so. The serum and CSF levels of NSE were much higher in the epileptic patients with tic or frequency.Conclusion NSE in serum and CSF could reach higher levels after seizures, suggesting that neuronal damage may result from seizures,especially when tic and frequency occur.
