Telomerase activity in the tissue adjacent to bladder cancer and its significance
- VernacularTitle:膀胱癌癌旁组织端粒酶活性检测的临床意义
- Author:
Yongsheng SONG
;
Chunyu PAN
;
Wei YANG
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Carcinoma;
Prognosis;
Telomerase activity
- From:
Chinese Journal of Urology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the telomerase activity in the tissue adjacent to bladder cancer and to investigate its clinical significance. Methods Telomerase activity was detected with telomeric repeat amplification PCR (TRAP) assay. The telomerase activity in the tissue adjacent to bladder cancer was evaluated. Results Telomerase activity was positive in the tissue samples adjacent to bladder cancer in 10 of the 24 cases(42%). Telomerase activity in the adjacent tissue has been related with the tumour grades and stages. The tumour recurrence was also related with the telomerase activity in the adjacent tissue. Conclusions The detection of telomerase activity in the tissue adjacent to bladder cancer could be a prognostic marker for bladder tumor recurrence.
