Study on the polymorphism of (CAG)n repeats within androgen receptor gene in patients with prostate cancer
- VernacularTitle:前列腺癌与雄激素受体基因(CAG)n重复多态性的关系
- Author:
Gang WANG
;
Guangchun CHEN
;
Xiaohui WANG
- Publication Type:Journal Article
- Keywords:
Prostate neoplasms;
Carcinoma;
Receptor,androgen;
Genes
- From:
Chinese Journal of Urology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between polymorphic (CAG)n repeats of androgen receptor(AR) gene and occurrence of prostate cancer (PC). Methods (CAG)n repeats of both malignant cells and adjacent nonmalignant cells from 34 paraffin embedded PCs, and that of peripheral blood cells from 2 PC patients were assessed using dsDNA cycle sequencing. Results The number of (CAG)n repeats in malignant cells was equal to that in adjacent nonmalignant cells from the same paraffin embedded PC; the mean of (CAG)n repeats in the 36 PC patients was 20.06 which was significantly smaller than that of normal men ( P 0.05). Conclusions Shortening of (CAG)n repeats within AR gene may be associated with the occurrence of PC.
