C-fos Protein Expression of the Rats on the Brain after 12 Hours Sleep Deprivation of Day and Night
- VernacularTitle:不同时段睡眠剥夺对大鼠脑内c-fos表达的影响
- Author:
Guoping SONG
- Publication Type:Journal Article
- Keywords:
Rats;
c-fos protein;
Immunocytochemistry;
Brain stem;
Sleep deprivation;
Circadian Rhythm
- From:Chinese Journal of Clinical Psychology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the brain mechanisms of sleep deprivation. Methods: Sprague-Dawley rats were sleep deprived by housing them on the small platforms over water. Controls were housed in the normal cage(CC) or on the large platforms over water(TC). The effects of SD on the expression of c-fos protein by immunocytochemistry were investigated. The duration of SD was about 12 hours. They were divided into two groups: early SD group (from 7:00 am) and the late SD group (from 19:00 pm). Results: SD resulted in different expression of c-fos protein at different fields of the brain. The main fields of brain stem were all connected with paradoxical sleep. Compared with the late SD, the early SD group showed higher fos protein expression on suprachiasmatic.Conclusion: The disruption of regular circadian rhythm may affect c-fos protein expression.
