Study on some factors incluencing on the effectiveness of semi-synthesis of fluoroalkyl ethers of dihydroartemisinine
- Author:
Nguyen Van Han
- Publication Type:Journal Article
- Keywords:
fluoroalkyl, dihydroartemisinine
- MeSH:
Artemisinins;
Therapeutics;
Solvents
- From:Pharmaceutical Journal
2004;44(1):8-10
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The study examined some factors (solvent, catalysis, temperature) affecting to fluoroalkyl ether subsynthesis effects of dihydroartemisinin. TF-DHA and PF-DHA, two fluoroalkylether derivatives of dihydroartermisinin was prepared by treatment of dihydroartermisin with appropriate fluoroalcohol in the presence of boron trifluoride etherate. The dicloromethan solvent is most efficient option for TF-DHA's preparation
