Effects of Moderate Alcohol Intake in the Bladder of the Otsuka Long Evans Tokushima Fatty Diabetic Rats.
10.3346/jkms.2015.30.9.1313
- Author:
Woong Jin BAE
1
;
Yong Sun CHOI
;
Su Jin KIM
;
Hyuk Jin CHO
;
Sung Hoo HONG
;
Sae Woong KIM
;
Tae Kon HWANG
;
Dai Jin KIM
;
Ji Youl LEE
Author Information
1. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea. uroljy@catholic.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Alcohols;
Diabetes Mellitus;
Urinary Bladder Disease
- MeSH:
Alcohol Drinking/adverse effects;
Animals;
Diabetes Mellitus, Type 2/*complications/*metabolism/pathology;
Ethanol/*toxicity;
Humans;
Rats;
Rats, Inbred OLETF;
Reactive Oxygen Species/*metabolism;
Urinary Bladder/*drug effects/*metabolism/pathology
- From:Journal of Korean Medical Science
2015;30(9):1313-1320
- CountryRepublic of Korea
- Language:English
-
Abstract:
Diabetes is related with a number of cystopathic complications. However, there have been no studies about the influence of alcohol consumption in the bladder of type 2 diabetes. Thus, we investigated the effect of moderate alcohol intake in the bladder of the Otsuka Long Evans Tokushima Fatty (OLETF) diabetic rat. The non-diabetic Long-Evans Tokushima Otsuka (LETO, n=14) and the OLETF control group (n=14) were fed an isocaloric diet; the LETO (n=14) and the OLETF ethanol group (n=14) were fed 36% ethanol 7 g/kg/day. After ten weeks, muscarinic receptors, RhoGEFs, myogenic change, and the level of oxidative stress were evaluated. Moderate alcohol intake significantly decreased excessive muscarinic receptor and Rho kinase expressions in the OLETF rats compared with the LETO rats. In addition, iNOS and collagen expression were not changed in the OLETF rats in spite of alcohol consumption. Superoxide dismutase levels, which is involved in antioxidant defense, in the LETO rats were significantly decreased after alcohol consumption, however those in the OLETF rats were similar. Moderate alcohol consumption reduces the oxidative stress, and may prevent molecular and pathologic changes of the bladder of rats with type 2 diabetes.
