Curcumin inhibits leukemia cell line HL_60 /ADR
- VernacularTitle:姜黄素对白血病耐药细胞HL_(60)/ADR的抑制作用
- Author:
Junqiong HUANG
;
Wanbang SUN
- Publication Type:Journal Article
- Keywords:
Curcumin HL60/DAR cell line Suppression Apoptosis
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract Objective:To explore the suppression of curcumin on leukemia cell line HL60/DAR. Methods: The suppression of curcumin onleukemia cell line HL60/DAR was studied by MTT;the apoptosis was studied by flow cytometric Annexin V/PI dual labeling technique and fluo-rescence microscope;the change in apoptosis related gene bcl-2 was studied by flow cytometry.Results: CUrcumin suppressed the growth ofHL60/DAR obviously IC50 were 8.94,5.2l,3.82 ?g/ml for 24,48,72 h respectively. Curcumin induced Hl60/DAR cells to apoptosisdeath. CUrcumin suppressed the expression of bcl-2. Conclusion: Curcumin can suppress the growth of HL60/DAR cells.
