Experimental Study on Developmental Toxicity of AlCl_3 to Rats' Embryo in Vitro
- VernacularTitle:AlCl_3致胚胎发育毒性的体外实验研究
- Author:
Benzhong ZHANG
;
Pu LI
;
Desheng WU
- Publication Type:Journal Article
- Keywords:
Aluminum;
Whole-embryo culture;
Developmental toxicity;
Animal, laboratory
- From:
Journal of Environment and Health
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
re To understand the developmental toxicity of aluminum and its mechanism. Methods The embryos of SD rats at the 9. 5th day after gestation were explanted and cultured in a whole-embryo culture system with exposure to AlCl3 at Al3+ concentrations of 0.6, 0.9, 1.2, 3.0, 6.0 and 9.0 ?g/ml for 48 hours. Using Brown's mor-phological scoring system, yolk sac diameter, crown-rump length, head length and embryonic dry weight were mea-sured. Results A certain dose-effect relationship (r= - 0.890? 0.973, P
