Effect of D-?-tocopherol on diabetic retinopathy via regulating protein kinase C activity
- VernacularTitle:D-?-生育酚调节蛋白激酶C活性对糖尿病视网膜病变的影响
- Author:
Bo ZHOU
;
Shuping WANG
;
Tao JIANG
- Publication Type:Journal Article
- Keywords:
Protein kinase C;
D ? tocopherol;
Na + K + exchanging ATPase;
Ca 2+ transporting ATPase;
Diabetic retinopathy
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
100% elevation of PKC activity in the retina, and administration of D ? tocopherol prevented the elevation of PKC activity and diabetes induced decrease of both Na + K + ATPase and Ca 2+ ATPase activities. D ? tocopherol achieved a complete prevention of augmented pericyte and endothelial cell profile areas and basement membrane thickening in the superficial and deep capillaries bed of diabetic retina but had no effect on blood glucose and HbA 1c . Conclusion Diabetes induced histopathological abnormalities are mostly mediated by PKC. D ? tocopherol reduces the ultrastructural lesions in retinal capillary bed induced by hyperglycemia.
