Detection and clinical significance of G-CSF receptor
- VernacularTitle:粒细胞集落刺激因子受体检测及其临床意义
- Author:
Juan FAN
;
Jian XU
;
Gongli XU
- Publication Type:Journal Article
- Keywords:
Flow cytomatry Leukemia Acute leukemia Graunlocyte colony-stimulating factor receptor
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate a method for G-CSFR and analyze its expression in acute leukemia. Methods:20 normal controls and acute leukemic patients were detected by G-CSF receptor antibody and flow cytometry, analyzed relationship between the level of G-CSFR expression and clinical manifestations. Results: G-CSFR expression rates of patients with acute leukemia were significantly lower than that of normal control(P0.05),while the G-CSFR expression rate were significant correlated with blast rate of bone marrow(r. =-0.614, P = 0.025) ;there were no correlation with G-CSFR expression and FAR subtype in acute myeloid leukemia. Conclusion :The method for detecting G-CSFR is very sensitive and differential ,acute leukemic patients have lower expression rate of G-CSFR.
