Effects of total gulcosides of triptergium wilfordii (T_Ⅱ) on the reproductive organs of transplant recipients
- VernacularTitle:雷公藤多甙对肾移植受体生殖器官的影响作用
- Author:
Yeyong QIAN
;
Bingyi SHI
;
Chunquan LIANG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Immunosuppressive agents
- From:
Chinese Journal of Urology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of total glucosides of triptergium wilfordii(T Ⅱ) on reproductive organs of transplant recipients. Methods 64 patients were divieded into two groups by whether or not using T Ⅱ.The model of renal transplantation in rats was established.The effects of T Ⅱ on reproductive organs of transplant recipients were observed in both clinical and animal experiments. Results Menstrual changes were evident in female patients,such as amenorrhea. T Ⅱ were fed 30 mg?kg -1 ?d -1 to the renal transplanted rats.Degenerative changes of the seminiferous epithelium could be found.The highest suscepitibility was sperms and the lowest spermatogonium.The ovaries in female rats were essentially normal. Conclusions There were significant effects of total glucosides of triptergium wilfordii on the reproductive systems of renal transplant recipients.
