Detection of uroplakin Ⅱ mRNA positive cells in peripheral blood of patients with urothelial cancer
- VernacularTitle:尿路上皮肿瘤患者外周血Uroplakin Ⅱ基因检测的意义
- Author:
Jiaju LU
;
Jiyi CHENG
;
Shanfeng TAN
- Publication Type:Journal Article
- Keywords:
Urinary tract;
Epithelioma;
Genes
- From:
Chinese Journal of Urology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of detecting circulating UP Ⅱ mRNA positive cells in patients with transitional cell carcinoma (TCC). Methods Expression of UP Ⅱ mRNA was examined with nested reverse transcriptase polymerase chain reaction (RT PCR) assay. Results UP Ⅱ mRNA positive cells were detected in 0% (0/26) of patients with superficial urothelial cancers (pT a～1 N 0M 0), 20.8% (5/24) of patients with invasive cancers (pT 2～4 N 0M 0), 50.0% (1/2) of regional node positive patients (pN 1～2 M 0),and 100.0% (2/2) of patients with distant metastases. Positive rates increased with tumor extension ( P
