The inhibitory effect of CD/5-FC system on the prostate cancer cell DU145 and RM-1 in vitro
- VernacularTitle:胞嘧啶脱胺酶/5-氧胞嘧啶基因系统对前列腺癌细胞系生长的抑制作用
- Author:
Zhengwang ZHANG
;
Yongkang ZHANG
;
Lianhua YIN
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Carcinoma;
Genes
- From:
Chinese Journal of Urology
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the inhibitory effect of CD/5 FC system on the prostate cancer cell DU145,RM 1 in vitro. Methods In vitro prostate cancer cells DU145 and RM 1 were infected by recombinant adenoviral vector and then the inhibitory effect and the bystander effect of CD/5 FC system were observed. Results CD/5 FC system had a remarkable inhibitory effect on prostate cancer cell DU145 and RM 1 in vitro, the inhibition rates being higher than 97% when infected by AdCMVCD after 4 days added with 15.5mmol/L 5 FC. A strong bystander effect could also be observed, more than 75% tumor cells being killed when only 10% were infected. Conclusions CD/5 FC system may serve as an effective gene therapeutic method.The existence of bystander effect makes itself available in the use of tumor treatment in vivo.
