Inhibitory effect of dimethyl sulfoxide on collagen formation
- VernacularTitle:二甲基亚砜抑制胶原蛋白形成的机制
- Author:
Yang XIA
;
Dongming CHEN
;
Zhaoji XIA
- Publication Type:Journal Article
- Keywords:
Sulfones;
Collagen;
Dilatation
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2002;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of inhibitory effect of dimethyl sulfoxide (DMSO) on the hyperplasia of the fibrous capsule around the tissue expander. Methods The experimental model was established in rats as follows: after implanting the expander on the back of rats, 30 % DMSO or normal saline was injected into the expander. The former was classified as experimental group, and the latter as control group. The cystic wall was resected after the skin and soft tissues were expanded. In situ hybridization and the immunohistochemical staining were used to determine the expression of typesⅠand Ⅲ of collagen and procollagen mRNA in the cystic walls. Results It was found that both the typeⅠand Ⅲ of collagen content and the expressing quantity of mRNA of procollagen in the cystic wall of the experimental group were less than those of control group. Conclusion The results imply that the mechanism that DMSO inhibits the expression of typesⅠand Ⅲ of collagen in the fibrous cystic wall may be achieved through down-regulating the genetic expression of procollagen in the fibroblasts.