Antibody response in mice after gastric larvae immunized with live and inactive attenuated Hepatitis A vaccine
- VernacularTitle:甲型肝炎减毒活疫苗及灭活疫苗灌胃免疫小鼠后的抗体应答
- Author:
Chen CHEN
;
Junjie TANG
;
Zhijun YANG
- Publication Type:Journal Article
- Keywords:
Live attenuated hepatitis virus A vaccine Intragastric immunization Antibody response Adjuvant
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To survey the antibody response to live and inactive attenuated hepatitis A vaccine immunized by gastrogavage in mice.Methods:The mice were immunized by gastrogavage with live or inactive vaccine of hepatitis virus A with or without gelatin.The sera and intestinal fluid were collected after two weeks at last immunization.The specific IgG,IgA were assayed by ELISA.Results:Both of live and inactive HAV vaccine can induce the antibody response in local and system after gastrogavage immunization,the level of antibody in serum of mice is higher than that immunized by intramuscularly injection (P
