Immune mechanical study of total glycoside from Cornus officinalis against rheumatoid arthritis
- VernacularTitle:山茱萸总苷抗类风湿关节炎免疫作用机理的初步研究
- Author:
Lili GUO
;
Yong ZHOU
;
Xudan WANG
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis Animal model Total glycosides from Cornus officinalis Specific-CⅡantibody Specific-CⅡ lymphocyte proliferation
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze immune mechanisms of total glycoside from Cornus officinalis (TGCO) against rheumatoid arthritis.Methods:Rat immunized by CⅡ in CFA were treated with TGCO ,at different times after immunization,CⅡ-specific antibodies in serum,lymphnode cells(LNC) IFN-? production was studied and cell proliferation response were also detected.Results:Treatment inhibit disease severity to a greater extent. TGCO effectively decreased anti-CⅡantibody titer in serum, considerably reduced IFN-? secretion before the onset arthritis and the acute stage of arthritis and suppressed T cell differentiation or proliferation.Conclusion:The both lead to supprese arthritis.
