The expression and clinical significance of IRF-1 gene in human leukemia
- VernacularTitle:IRF-1基因在白血病中的表达及其临床意义
- Author:
Donghong LIN
;
Tingbo LIU
;
Shaoyuan WANG
- Publication Type:Journal Article
- Keywords:
Leukemia Gene IRF-1 RT-PCR
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression and clinical significance of IRF-1 gene in leukemia.Methods:Revert polymerase chain reaction(RT-PCR) and gel image analysis system were used to analyse the expression of IRF-1 gene in 77 leukemias and 4 leukemic cell lines.Results:IRF-1 gene was found in 18 patients with acute leukemia.Significant low expression of IRF-1 gene was detected in the acute leukemia?chronic myelogenous leukemia(CML) and 3 leukemic cell lines HL 60 K 562 and U 937 compared with the normal and non-mallignant hematonosis (P
