Effects of Environmental Lead Exposure on Immune System in Preschool Children
- VernacularTitle:环境铅暴露对学龄前儿童免疫系统的影响
- Author:
Li SUN
;
Zhengyan ZHAO
;
Rong LI
- Publication Type:Journal Article
- Keywords:
Lead poisoning;
Children preschool;
Immune, cell;
T_lymphocyte subset
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of environmental lead exposure on immune system in preschool children. Methods The blood lead levels of 217 preschool children were determined by graphite furnance atomic absorption spectrophotometry. The distribution of T_lymphocyte subsets: CD 3+,CD 3+CD 4+,CD 3+CD 8+, B cells (CD 3- CD 19+), NK cells (CD 3-CD 16+CD 56-) were analyzed by flow cytometer, the levels of serum immunoglobulin G and immunoglobulin M were determined by scattering turbidimetry, the levels of serum immunoglobulin E were examined with ELISA. Results The mean level of blood lead of 217 preschool children was (0.46?0.27)?mol/L(range:0.11～2.71 ?mol/L). The blood lead levels of 63 preschool children were ≥0.48 ?mol/L. 38 preschool children among 63 preschool children with blood lead level of ≥0.48 ?mol/L were selected as the high_blood_lead group, 35 preschool children with blood lead levels of 0.05). Condusion The blood lead levels of ≥0.48 ?mol/L presented adverse effects on the T_lymphocyte subsets.
