Effects of Organic Extracts of Drinking Water and Source Water on DNA Damages of Human Peripheral Blood Lymphocytes
- VernacularTitle:某市水中有机提取物对人外周血淋巴细胞DNA的损伤作用
- Author:
Juxiang WANG
;
Yongxia HAN
;
Yumei GAO
- Publication Type:Journal Article
- Keywords:
Drinking water;
Organic extract;
Single cell gel electrophoresis;
DNA damage
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the effects of drinking water and source water on DNA breakage of human peripheral blood lymphocytes (HPBL). Methods The organic compounds in drinking water and source water were adsorbed by GDX_102 resin for solid phase of gas choromatography. DNA damages of lymphocytes were detected by single cell gel electrophoresis. Results At the same exposure doses to organic extracts of water, the DNA damages of HPBL exposed to organic extracts of surface water were heavier than those exposed to organic extracts of deep underground water, and heavier DNA damages were also observed in HPBL exposed to organic extracts of finished water from water plant treating ground source water compared with those exposed to organic extracts of finished water from water plant treating deep underground source water. Significant dose_response relationships were observed between the exposure doses of organic extracts of water samples and the degrees of DNA damages of HPBL. Conclusion The organic extracts of source water samples collected from surface water and ground water and its tap water samples could cause DNA breakages of HPBL in different degrees in a certain city.
