Antagonistic Effects of Organic Extracts of Fruit of Chinese Wolfberry on Chromium (Ⅵ)-induced Mutation in Human Peripheral Blood Lymphocytes
- VernacularTitle:枸杞提取物拮抗六价铬对人外周血淋巴细胞致突变作用研究
- Author:
Dong_mei GUO
;
Shu_e WANG
;
Hou_quan XU
- Publication Type:Journal Article
- Keywords:
Fruit of Chinese Wolfberry;
Chromium;
Mutagenesis;
Antagonists;
Lymphocyte;
Unscheduled DNA synthesis
- From:
Journal of Environment and Health
1992;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antagonistic effect of organic extracts of Fruit of Chinese Wolfberry (FCW) on chromium (Ⅵ) _induced mutation. Methods Using unscheduled DNA synthesis (UDS) assay, the effects of 0.02 g/ml, 0.01 g/ml and 0.005 g/ml organic extracts of FCW on UDS induced by potassium bichromate [0.31 ?g/ml Chromuim (Ⅵ)] in human peripheral blood lymphocytes were determined. The effects of the order of adding organic extract of FCW and potassium bichromate into cultured lymphocyte suspension on UDS were observed at the same time. Results The value of CPM revealed a significantly higher level in positive control group exposed to 0.31 ?g/ml chromium (Ⅵ) compared with that in negative control group exposed to disstilled water (P
