Intravesical instillation of mitoxantrone for the prevention of postoperative recurrence of bladder cancer
- VernacularTitle:米托蒽醌灌注预防膀胱癌术后复发的疗效观察(附98例报告)
- Author:
Lianxi QU
;
Jianjun JIN
;
Jigong WANG
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Mitoxantrone;
Administration,intravesical
- From:
Chinese Journal of Urology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate intravesical instillation of mitoxantrone(MTZ) for the prevention of postoperative recurrence of bladder cancer. Methods Intravesical instillation of 12 mg MTZ dissolved in 50 ml normal saline and retained in bladder for 2 hours were given to bladder cancer patients postoperatively once a week for 8 weeks and subsequently once a month for 12 months.Kidney and liver function,blood counting,urinalysis and cystoscopy were taken periodically.The systemic and local reactions were recorded every time after the intravesical instillation. Results All of the 98 cases were followed up for 6 to 24 months with a mean of 13 months.The recurrence rate was 6.2%.There was no generalized side effect. Conclusions Intravesical instillation of MTZ was efficacious for the prevention of postoperative recurrence of superficial bladder cancer with safety and less side effect.So it can be widely used in such patients.
