Expression and significance of clusterin in prostate neoplasm
- VernacularTitle:聚集素在前列腺癌中的表达及意义
- Author:
Liqun ZHOU
;
Xuezhen YANG
;
Lili LIANG
- Publication Type:Journal Article
- Keywords:
Prostate neoplasms;
Clusterin;
Apoptosis;
Reverse transcriptase polymerase chain reaction
- From:
Chinese Journal of Urology
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression and significance of antiapoptosis facter-clusterin in prostate neoplasm. Methods Reverse transcriptive polymerase chain reaction(RT PCR) was used to examine the expression level of clusterin in prostate cancer tissues(3 cases),prostate cancer cell line PC3M and normal prostate tissues(3 cases). Results Compared with the internal marker gene ? actin , the expression level of clusterin in prostate cancer is much higher than that of normal prostate. Conclusions The high expression level of clusterin in prostate cancer indicates that clusterin may play an important role in the biological characteristics of prostate cancer through the antiapoptosis pathway.
