Relation between apoptosis and proliferation or genes expression after chemotherapy in ovarian eithelial carcinoma
- VernacularTitle:化疗后卵巢癌细胞凋亡、增殖、基因表达的相关性
- Author:
Jinfeng LIANG
;
Liyin LIU
;
Shujun CHENG
- Publication Type:Journal Article
- Keywords:
ovarian neoplasms;
apoptosis;
deoxynucleotidyl transferase;
oncogens
- From:China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the apoptosis and proliferation in ovarian cancer and the relationship between gene and the histological grading as well as response to chemotherapy. Methods:In our study apoptosis in fifty fresh samples of epithelial ovarian carcinomas were evaluated by TDT (terminal deoxynucleotidyl transferase) assay. We used the techniques of immunohistochemistry to detect the proliferation and the protein expression of bcl-2,bax and p53 gene.Results:In 66% (30/50) samples of fresh epithelial ovarian carcinoma apoptosis was observed in different degrees. Our results showed that PCAN and p53 expression in poorly differentiated ovarian carcinoma is higher than that in well middle differentiated (P
