Expression of Fas/FasL in lung cancer and its significance
- VernacularTitle:Fas/FasL在肺癌中的表达及意义
- Author:
Congying XIE
;
Shixiu WU
;
Kang YU
- Publication Type:Journal Article
- Keywords:
lung neoplasms;
immune evasion;
metastasis
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression and significance of Fas/FasL in lung cancer.Methods:The expression of Fas/FasL was detected in 42 cases of non-small-cell lung cancer by immunohistochemistry. Results:Out of 42 cases, Fas was positive in 22 cases (52.3%) and FasL was positive in 24 cases(57.1%), there was no correlation between the expression of Fas and FasL. The expression of Fas/FasL was not different in squamous cell carcinoma and adenocarcinoma. The stage of lung cancer had a positive correlation with the expression of FasL, while was no correlation with Fas expression.Conclusions:The expression of Fas/FasL in lung cancer may play an important role in the escape of tumor cells from immune function and FasL is worthy of further research in metastasis of lung neoplasms.
