Therapy of murine gastric cancer by 5-FC/CD suicide gene system combined with HSP-PC tumor vaccine
- VernacularTitle:氟胞嘧啶/胞嘧啶脱氨酶自杀基因疗法结合热休克蛋白多肽复合物治疗小鼠胃癌
- Author:
Ping CHEN
;
Zhilin CHEN
;
Lichun XU
- Publication Type:Journal Article
- Keywords:
suicide gene;
shock protein 70-peptide complexes;
MFC gastric cancer cells
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To investigate the antitumor effect of 5-fluorocytosine/cytosine deaminase (5FC/CD) suicide gene system combined with heat shock protein 70 peptide complexes(HSP70-PC) tumor vaccine.Methods:5-FC was administrated intraperitoneally after recombinant adenoviruses carrying E.coli CD gene were injected into murine tumor tissue. At the same time,mice bearing tumor were inoculated s.c. with HSP70-PC. Results:The combined therapy led to reduction in tumor growth, and complete tumor regression was observed in 70% of the mice. After the combined therapy, the tumor tissue showed more CD + 4 and CD + 8T cells infiltration, and the murine CTL activities increased significantly. Conclusions:The therapy combining 5-FC/CD system with HSP-PC tumor vaccine is very effective in murine gastric cancer, and has potential for clinical usage.
