Ki-67 antigen's expression in benign and malignant neoplasms of colorectum and its clinical significance
- VernacularTitle:大肠良、恶性肿瘤Ki-67抗原的表达及其意义
- Author:
Xueliang GUO
;
Zonglin GUO
;
Lina FU
- Publication Type:Journal Article
- Keywords:
colorectal neoplasms;
Ki-67 antigen;
flow cytometry detetection
- From:
China Oncology
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose:To study the expression of Ki-67 antigen in normal mucosae,benign and malignant neoplasms of colorectum and its clinical significance. Methods:33 cases of carcinomas,13 cases of benign neoplasms and 13 cases of normal mucosae of colorectum were collected. Ki-67 antigen was detected using flow cytometry.Results:The Ki-67 antigen positive fraction of normal mucosae,benign and malignant neoplasms of colorectum were 2.65%?1.51%,6.38%?2.51%,18.52%?8.53% respectivly, there being significant difference between the groups(P0.05). Conclusions:Ki-67 antigen expression is a valuable marker to distinguish the normal mucosae,benign and malignant neoplasms of colorectum. Ki-67 antigen expression has no relation with tumor size,type of histopathology,Dukes stage,location,length of illness history,age,sex of the colorectal carcinoma patients.
